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糖皮质激素作为原发性肾病综合征最重要和首选的治疗药物,在临床上使用已逾半个多世纪,尽管大多数儿童原发性肾病综合征对糖皮质激素敏感而预后较好,但仍有约10%～20%表现为激素耐药性肾病综合征,激素耐药机制已成为肾脏疾病研究的热点课题。该文就其近年来有关国内外儿童原发性肾病综合征糖皮质激素耐药机制研究进展作一综述。
Glucocorticoid, the most important and preferred therapeutic drug for primary nephrotic syndrome, has been used clinically for more than half a century. Although most children with primary nephrotic syndrome have a better prognosis than glucocorticoid, Still about 10% to 20% of the performance of hormone-resistant nephrotic syndrome, hormone resistance mechanism has become a hot topic of kidney disease research. This review summarizes recent advances in research on mechanisms of glucocorticoid resistance in children with primary nephrotic syndrome in China and abroad.