目的：观察杏仁核内微量注射环磷酸腺苷（ｃＡＭＰ）和腺苷三磷酸（ＡＴＰ）对睡眠和觉醒的影响。方法：多导睡眠描记。结果：ｃＡＭＰ可减少觉醒（Ｗ），缩短入睡潜伏期（ＳＷＳ１），增加慢波睡眠（ＳＷＳ）和总睡眠时间（ＴＳＴ）；ＡＴＰ对睡眠无显著影响。结论：外源性ｃＡＭＰ可促进睡眠，抑制觉醒；杏仁核是睡眠觉醒周期调节的重要部位。 Objective: To observe the effect of microinjection of cAMP and ATP on sleep and wakefulness in amygdala. Methods: Polysomnography. Results: cAMP decreased awakening (W), shortened the latency to go to sleep (SWS1), increased SWS and total sleep time (TST); ATP had no significant effect on sleep. Conclusion: Exogenous cAMP can promote sleep, inhibit awakening; amygdala is an important part of sleep-wake cycle regulation.