目的研究临床分离的白色念珠菌抗性基因qac E△1-s u l I、qac A/B的携带情况及其对醋酸氯己定的抗性水平。方法采用PCR方法测定qac E△1-s u l I、qac A/B基因,通过沙氏培养液稀释法检测其对消毒剂的抗性变化,并于白色念珠菌标准菌株进行比较。结果临床分离的24株白色念珠菌,其抗性基因qac E△1-Sul I、qac A/B检测均为阴性。醋酸氯己定对其中11株的最小抑菌浓度(MIC)低于标准菌株,其余均与标准菌株相同。其中,有1株白色念珠菌的最小杀菌浓度(MBC)高于标准菌株,7株的MBC值低于标准菌株,其余均与标准菌株相同。结论白色念珠菌对醋酸氯己定可能尚未产生抗性。 OBJECTIVE To study the carriage of qac E △ 1-s u l I, qac A / B and their resistance to chlorhexidine acetate clinically isolated Candida albicans. Methods The qac A / B gene of qac E △ 1-s u l I and qac A / B was detected by PCR. The changes of the resistance to disinfectant were detected by the method of dilution culture. The comparison was made with the standard strain of Candida albicans. Results Twenty-four C. albicans isolates were negative for qac E △ 1-Sul I and qac A / B. The minimum inhibitory concentration (MIC) of 11 strains of chlorhexidine acetate was lower than that of the standard strains, and the rest were the same as the standard strains. Among them, the minimum bactericidal concentration (MBC) of one strain of Candida albicans was higher than that of the standard strain. The MBC value of seven strains was lower than that of the standard strains, and the rest were the same as the standard strains. Conclusion Candida albicans may not have resistance to chlorhexidine acetate.