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Tumor growth without size restriction depends on vascularsupply.The ability of tumor to induce new blood-vesselformation has been a major focus of cancer research overthe past decade.It is now known that members of thevascular endothelial growth factor and angiopoietin families,mainly secreted by tumor cells,induce tumor angiogenesis,whereas other endogenous angiogenic inhibitors,includingthrombospondin-1 and angiostatin,keep tumor in dormancy.Experimental and clinical evidence has suggested that theprocess of tumor metastasis depends on angiogenesis orlymphangiogenesis.This article summarizes the recentresearch progress for some basic pro-or anti-angiogenicfactors in tumor angiogenesis.
Tumor growth without size restriction depends on vascularsupply.The ability of tumor to induce new blood-vesselformation has been a major focus of cancer research overthe past decade. It is now known that members of the vascular endothelial growth factor and angiopoietin families, mainly secreted by tumor cells, induce tumor angiogenesis, and other other endogenous angiogenic inhibitors, including thrombospondin-1 and angiostatin, keep the tumor in dormancy. Experimental and clinical evidence has suggested that the process of tumor metastasis depends on angiogenesis or lymphangiogenesis. This article summarizes the recent research progress for some basic pro- or anti-angiogenic factors in tumor angiogenesis.