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细胞因子是一类免疫调节剂,将分泌细胞因子的生物制剂用于某些疾病的免疫治疗已成为当前的一个热点研究领域。乳球菌是一种新型疫苗载体,本文综述了白细胞介素、干扰素、肿瘤坏死因子α、IFN-γ诱导的蛋白10和粒细胞-巨噬细胞集落刺激因子等细胞因子重组乳球菌疫苗的构建及其作用机制等方面的研制现状。
Cytokines are a class of immunomodulatory agents. It has become a hot research field to apply cytokine-secreting biological agents to the immunotherapy of certain diseases. Lactococcus is a new type of vaccine vector. This review summarizes the construction of recombinant Lactococcus Vaccine against cytokines such as interleukin, interferon, tumor necrosis factor α, IFN-γ-induced protein 10 and granulocyte-macrophage colony-stimulating factor And its mechanism of action and other aspects of the status quo.