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研究目的:探讨在非肥胖、高血压和糖尿病的中国中青年群人中非酒精性脂肪性肝病(NAFLD)和动脉硬度的关系。创新要点:在非肥胖、高血压和糖尿病的中青年人群中,阐明NAFLD和动脉硬度的关系,对预防和诊断早期动脉硬度有重要临床意义。研究方法:在非肥胖、高血压和糖尿病的中青年体检人群中进行一项大型横断面研究。用B超诊断脂肪肝,用臂踝脉搏波指数(baPWV)测量动脉硬度,根据是否有NAFLD和baPWV水平分组。重要结论:NAFLD组患者的baPWV水平明显高于对照组((1321±158)cm/s vs.(1244±154)cm/s;P<0.001),NAFLD患病率在baPWV升高组明显高于baPWV正常组(29.3%vs.16.9%;P<0.001),且NAFLD患病率随baPWV水平和动脉硬度程度的升高而升高(两者趋势P值<0.001)。多因素线性回归分析表明,NAFLD发生与baPWV独立相关。因此,在非肥胖、高血压和糖尿病的中国中青年群人中,NAFLD发生与动脉硬度密切相关。
The purpose of this study was to investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and arterial stiffness in a Chinese population of young and middle-aged people without obesity, hypertension and diabetes. Innovative points: In non-obese, high blood pressure and diabetes in young people, to clarify the relationship between NAFLD and arterial stiffness, the prevention and diagnosis of early arterial stiffness has important clinical significance. Research Methods: A large cross-sectional study was conducted among young and middle-aged medical non-obese, hypertensive and diabetic subjects. Fatty liver was diagnosed by B-mode ultrasound and arterial stiffness was measured by brachial-ankle pulse wave index (baPWV), based on the presence or absence of NAFLD and baPWV. Important conclusion: The level of baPWV in NAFLD group was significantly higher than that in control group (1321 ± 158 cm / s vs. 1244 ± 154 cm / s; P <0.001). The prevalence of NAFLD was significantly higher in baPWV In normal baPWV group (29.3% vs.16.9%; P <0.001), the prevalence of NAFLD increased with the increase of baPWV and arterial stiffness (both P <0.001). Multivariate linear regression analysis showed that the occurrence of NAFLD was independently associated with baPWV. Therefore, non-obese, high blood pressure and diabetes in young people in China, the occurrence of NAFLD and arterial stiffness are closely related.