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目的研究缬沙坦对高血压左室肥厚 (LVH)患者的左室结构、室性心律失常及心肌缺血的影响。方法 86例原发性高血压左室肥厚患者随机分为 2组 :治疗组每天口服缬沙坦 80mg ,对照组第天口服非洛地平 5mg。平均 12个月 ,观察用药后血压、左室结构、室性心律失常及心肌缺血的变化。结果用药后 2组收缩压 (SBP)和舒张压 (DBP)均显著降低 (P <0 .0 1) ;室间隔厚度 (IVST)及左室后壁厚度 (LVPWT)均变薄 (P <0 .0 1) :左室重量指数 (LVMI)明显减少 (P <0 .0 1) ;室性心律失常发生率明显降低 (P <0 .0 1) ;发作性ST段压低的发生率及持续时间明显降低 (P <0 .0 1) ;对照组各项指标无明显变化 (P <0 .0 5 )。结论在无冠心病证据的原发性高血压左室肥厚的患者中 ,长期应用缬沙坦具有良好的降压效果 ,同时还可逆转LVH ,降低室性心律失常发生率 ,减少心肌缺血的发生率及持续时间 ,改善患者的预后
Objective To investigate the effects of valsartan on left ventricular structure, ventricular arrhythmia and myocardial ischemia in patients with hypertensive left ventricular hypertrophy (LVH). Methods Eighty-six patients with essential hypertension with left ventricular hypertrophy were randomly divided into two groups: the treatment group received oral valsartan 80 mg daily, while the control group received oral felodipine 5 mg on the first day. After an average of 12 months, the changes of blood pressure, left ventricular structure, ventricular arrhythmia and myocardial ischemia were observed. Results Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were significantly decreased (P <0.01), and the thickness of interventricular septum (IVST) and left ventricular posterior wall thickness (LVPWT) .0 1): Left ventricular mass index (LVMI) decreased significantly (P <0.01); ventricular arrhythmia incidence decreased significantly (P <0.01); incidence of episodic ST segment depression and sustained The time was significantly lower (P <0.01); no significant change in the control group indicators (P <0. 05). Conclusion Long-term valsartan has a good antihypertensive effect in patients with essential hypertension without left ventricular hypertrophy without evidence of coronary heart disease. It can also reverse LVH, reduce the incidence of ventricular arrhythmia and reduce myocardial ischemia The incidence and duration, improve the patient’s prognosis