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目的探讨Survivin基因在乳腺良性肿瘤、乳腺癌组织中表达的临床意义及其与血管内皮生长因子(VEGF)表达的关系。方法应用免疫组织化学法(SP法)检测14例乳腺纤维腺瘤、62例乳腺癌组织中Survivin基因和VEGF的表达。结果Survivin在乳腺癌和乳腺纤维腺瘤组织中表达的阳性率分别为67.7%和7.1%(P<0.01)。而VEGF在乳腺癌和纤维腺瘤组织中的阳性率分别为72.6%和42.9%(P<0.05)。乳腺癌组织中Survivin表达水平与VEGF表达相关(peearson系数0.569),与患者临床病理特征无关(P>0.05)。结论Survivin基因在乳腺癌组织的发生中可能起一定的作用,且Survivin基因可能参与了肿瘤的血管形成。
Objective To investigate the clinical significance of Survivin expression in breast neoplasm and breast cancer and its relationship with the expression of vascular endothelial growth factor (VEGF). Methods The expression of Survivin gene and VEGF in 14 cases of breast fibroadenoma and 62 cases of breast cancer were detected by immunohistochemistry (SP method). Results The positive rates of Survivin expression in breast cancer and breast fibroadenoma were 67.7% and 7.1%, respectively (P <0.01). The positive rates of VEGF in breast cancer and fibroadenoma were 72.6% and 42.9%, respectively (P <0.05). The expression of Survivin in breast cancer was correlated with the expression of VEGF (peearson coefficient 0.569), but not with clinicopathological features (P> 0.05). Conclusion Survivin gene may play a role in the development of breast cancer, and Survivin gene may be involved in tumor angiogenesis.