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目的探讨骨髓增生异常综合征(MDS)患者血清甲状腺激素水平的变化。方法检测36例骨髓增生异常综合征患者和30例健康体检者(对照组)血清甲状腺激素水平。结果MDS患者血清总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)水平显著低于对照组,两组比较差异有统计学意义(P<0.05),而血清总甲状腺素(TT4)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平比较差异无统计学意义(P>0.05)。结论骨髓异常综合征患者存在正常甲状腺功能病态综合征中的低T3综合征,且可能对判断病情、观察疗效有一定临床价值。
Objective To investigate the changes of serum thyroid hormones in patients with myelodysplastic syndrome (MDS). Methods Serum thyroid hormone levels were measured in 36 patients with myelodysplastic syndrome and 30 healthy controls (control group). Results The levels of serum total triiodothyronine (TT3) and free triiodothyronine (FT3) in patients with MDS were significantly lower than those in the control group (P <0.05), while the total serum thyroid There was no significant difference in the levels of TT4, FT4 and TSH (P> 0.05). Conclusion The patients with myelodysplastic syndrome have low T3 syndrome in normal thyroid functional syndrome and may have certain clinical value in judging the disease and observing the curative effect.