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目的 评估非限制饮食的中、晚期慢性肾衰 (CRF)患者饮食蛋白摄入 (DPI)和营养状况。方法 在 36例中、晚期透析前CRF患者和 2 0例正常对照组中 ,测定DPI和营养指标 ,包括血清白蛋白 (Alb)、转铁蛋白 (TF)、前白蛋白 (pre Alb)、胰岛素样生长因子 1(IGF 1)。结果 CRF患者DPI(0 78± 0 2 5 )g·kg-1·d-1低于正常对照组 (1 0 4± 0 31)g·kg-1·d-1,P <0 0 1;Alb、TF亦显著减低 (P均 <0 0 1)。其中 10例CRF患者DPI <0 6 g·kg-1·d-1(2 8% ) ;DPI <0 6g·kg-1·d-1的CRF患者 (n =10 )与DPI≥ 0 6g·kg-1·d-1(n =2 6 )比较 ,Alb为 (2 7 7± 6 1) g·L-1、(35 3± 8 9) g·L-1,TF为 (1 5 8± 0 31) g·L-1、(2 74± 0 5 6 ) g·L-1,pre Alb为 (0 2 3± 0 0 8) g·L-1、(0 33± 0 10 ) g·L-1,P <0 0 1;IGF 1(1 36± 0 30 )nmol·L-1、(2 2 4± 0 6 2 )nmol·L-1,P<0 0 5。结论 大多数中、晚期CRF患者在透析前已发生营养不良 ,而伴有低饮食蛋白摄入患者更为明显。应适时监测并纠正营养不良的发生
Objectives To assess dietary protein intake (DPI) and nutritional status in patients with unrestricted diet for patients with chronic renal failure (CRF). Methods DPI and nutritional indicators, including serum albumin (Alb), transferrin (TF), prealbumin (Pre Alb), insulin, and insulin were measured in 36 patients with advanced to advanced CRF and 20 normal controls Like growth factor 1 (IGF 1). Results The DPI (0 78 ± 0 2 5) g · kg-1 · d-1 in CRF patients was lower than that of the control group (104 ± 0 31 g · kg-1 · d-1, P <0.01) Alb, TF also significantly reduced (P <0 01). The CRF patients (n = 10) with DPI <0 6g · kg-1 · d-1 and DPI ≥ 0 6g · Alb was (277 ± 6 1) g · L-1, (35 3 ± 8 9) g · L-1, and TF was (1 5 8) kg -1 · d -1 (n = 2 6) (0 23 ± 0 0 8) g · L-1, (0 33 ± 0 10) g · L -1, (2 74 ± 0 56) g · L- · L-1, P <0.01; IGF 1 (36 ± 0 30) nmol·L-1, (22 4 ± 0 6 2) nmol·L-1, P <0.05. Conclusions Most patients with advanced or advanced CRF had malnutrition before dialysis, whereas those with low dietary protein intake became more apparent. Malnutrition should be monitored and corrected in due course