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Gleeson等对1993年11月至1995年5月间接诊的49例结肠炎患者进行了前瞻性研究。其中37例(76％)有过非甾体抗炎药(NSAIDs)或水杨酸类药物服药史,口服布洛芬者居首(16例),其次为口服双氯灭痛者(15例),口服水杨酸者为7例,口服NSAIDs后出现结肠炎患者的平均年龄为45岁(24～91岁,女性20例),其余的平均年龄为37岁(24～73岁,女性10例)。患者皆无结肠炎史,且服药后出现的常见症状为腹泻、直肠出血或腹痛,大便培养阴性,结肠镜检确诊。 结肠镜下发现,NSAIDs引起的结肠炎,既包括直肠末端的溃疡性结肠炎,又有近端的节段性结肠炎,罹患部位出现红斑、水肿、腺管脓肿、溃疡、炎症浸润等,但无肉芽肿出现。
Gleeson et al conducted a prospective study of 49 patients with colitis admitted between November 1993 and May 1995. Of the 37 patients (76%) who had taken NSAIDs or salicylates, 16 were oral ibuprofen, followed by 15 patients with oral diclofenac, The average age of patients with colitis after oral administration of NSAIDs was 45 years (range, 24 to 91 years, 20 women) and the average age was 37 years (24 to 73 years, 10 females). Patients had no history of colitis, and the common symptoms that occurred after taking medicine were diarrhea, rectal bleeding or abdominal pain, stool culture negative, and colonoscopy. Colonoscopy found that NSAIDs caused colitis, both at the distal rectal ulcerative colitis, there are proximal segmental colitis, erythema, edema, ductal abscess, ulcer, inflammatory infiltration, etc., but the affected area, No granuloma appeared.