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目的观察热毒宁注射液治疗儿童急性上呼吸道感染的临床疗效。方法将610例急性上呼吸道感染患儿随机分为治疗组和对照组。治疗组310例,对照组300例,治疗组应用热毒宁注射液静脉滴注,对照组应用利巴韦林静脉滴注,2组均为1次/d,连用3～5d,2组均予以常规液体疗法及对症治疗。评价2组疗效,观察药物副作用。结果治疗组的平均退热时间、咽痛消失时间、咳嗽消失时间均显著短于对照组(P均<0.05)。治疗组的显效率、总有效率分别为40.6%、90.3%,均显著优于对照组(P<0.05)。2组均未观察到明显不良反应。结论热毒宁注射液治疗儿童急性上呼吸道感染的疗效优于利巴韦林注射液,疗效显著,安全性较高,值得临床推广使用。
Objective To observe the clinical efficacy of Rendunning injection in treating acute upper respiratory tract infection in children. Methods A total of 610 children with acute upper respiratory tract infection were randomly divided into treatment group and control group. 310 cases in the treatment group and 300 cases in the control group. The treatment group was given intravenous injection of Revinu injection, while the control group was treated with ribavirin intravenously. The two groups were treated once daily for 3-5 days, To conventional liquid therapy and symptomatic treatment. Evaluation of two groups of curative effect, observe the drug side effects. Results The average time of fever, disappearance of sore throat and disappearance of cough in treatment group were significantly shorter than those in control group (all P <0.05). The effective rate and total effective rate of the treatment group were 40.6% and 90.3%, respectively, which were significantly better than those of the control group (P <0.05). No significant adverse reactions were observed in both groups. Conclusion Reveduning injection in children with acute upper respiratory tract infection is superior to ribavirin injection, with significant curative effect and high safety, which is worthy of clinical promotion.