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应用前瞻性研究观察２５例恶性脑胶质瘤（ｍａｌｉｇｎａｎｔｇｌｉｏｍａｓ，ＭＧ）患者术前１～３ｄ（Ｐ０）、术后３～９ｄ（Ｐ１）及１３～２１ｄ（Ｐ２）机体凝血和纤溶系统的动态变化以及周围静脉血栓（ｐｅｒｉｐｈｅｒａｌｖｅｎｏｕｓｔｈｒｏｍｂｏｓｉｓ，ＰＶＴ）的发病率。结果显示，所有患者Ｐ０～Ｐ２均处于凝血系统激活和纤溶系统抑制状态，术后ＰＶＴ发病率为２２％（４／１８）。７例用低分子肝素预防者无ＰＶＴ发生。作者认为ＭＧ患者体内凝血系统激活及纤溶系统抑制状态是ＰＶＴ的重要原因。
A prospective study was conducted to investigate the changes of coagulation and fibrinolytic system in 25 patients with malignant glioma (MG) 1 ~ 3d (P0), 3 ~ 9d (P1) and 13 ~ 21d Changes and the incidence of peripheral venous thrombosis (PVT). The results showed that all patients P0 ~ P2 were in the coagulation system activation and fibrinolytic system inhibition, postoperative incidence of PVT was 22% (4/18). 7 cases of low molecular weight heparin prevention without PVT occurred. Authors believe that MG patients with coagulation system activation and fibrinolytic system inhibition status is an important cause of PVT.