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目的:探讨N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)对心力衰竭患者预后的预测价值。方法:检测206例患者不同时间的血浆NT-proBNP浓度,分析不同病因及不同分级心力衰竭患者血浆NT-proBNP浓度的比较结果,并分析NT-proBNP与心血管事件发生的关系。结果:不同病因患者的NT-proBNP含量比较,差异无统计学意义(P>0.05);血浆NT-proBNP浓度随心力衰竭的分级增大而升高(P<0.05);随访发生心血管事件患者的左室射血分数低于未发生心血管事件者(P<0.05);NT-proBNP浓度与是否发生心血管事件明显相关(P<0.05);死亡组入院时血浆NT-proBNP浓度高于存活组,差异有统计学意义(P<0.05)。结论:血浆NT-proBNP浓度在患者发生心力衰竭时显著升高,其检测值越高,患者发生心血管事件的可能性越大,其对心力衰竭患者再次发生心血管事件的预测具有一定的价值。
Objective: To investigate the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with heart failure. Methods: The plasma concentrations of NT-proBNP in 206 patients at different times were detected. The plasma concentrations of NT-proBNP in different etiologies and in patients with different grades of heart failure were analyzed. The relationship between NT-proBNP and cardiovascular events was analyzed. Results: There was no significant difference in NT-proBNP levels among different etiologies (P> 0.05). The plasma concentration of NT-proBNP increased with the increase of heart failure grade (P <0.05). The follow-up of patients with cardiovascular events (P <0.05). The concentration of NT-proBNP was significantly correlated with the occurrence of cardiovascular events (P <0.05). The plasma concentrations of NT-proBNP in the death group were higher than those in the survival group Group, the difference was statistically significant (P <0.05). Conclusion: The plasma NT-proBNP concentration in patients with heart failure was significantly higher, the higher the test value, the greater the possibility of patients with cardiovascular events, and its re-occurrence of cardiovascular events in patients with heart failure has some value in the prediction of cardiovascular events .