【摘 要】
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Dear Editor,Base editors (BEs) based on the CRiSPR/Cas9 system,including cytosine base editors and adenine base editors, which can efficiently perform four tran
【机 构】
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Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding,Beijing Academy of Agricul
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Dear Editor,Base editors (BEs) based on the CRiSPR/Cas9 system,including cytosine base editors and adenine base editors, which can efficiently perform four transition mutations (C·G-to-T·A and A·T-to-G·C), have been well studied and widely used to produce base mutations in a variety of organisms, including i nplants such as rice.However, manipulation of many agronomic traits in crops may require the other eight nucleotide substitutions (A·T-to-C·G, C·G-to-A·T, T·A-to-A·T and G·C-to-C·G).
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