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目的:探讨聚乙二醇干扰素α-2a联合双环醇治疗高转氨酶水平慢性乙型肝炎的疗效。方法:收治慢性乙型肝炎患者68例,根据不同用药方法,将其随机分为对照组及试验组各34例。对照组给予双环醇联合国产短效干扰素(凯因益生)治疗,试验组则给予聚乙二醇干扰素α-2a联合双环醇治疗。比较分析两组患者血清中ALT与AST含量、血清表面抗原含量以及乙肝病毒的DNA转阴率。结果:经有效治疗后,两组患者血清中ALT与AST含量、血清表面抗原含量以及乙肝病毒的DNA转阴率均呈现明显下降趋势,但试验组的下降趋势更为明显。结论:聚乙二醇干扰素α-2a联合双环醇对乙型肝炎病毒具有的抑制与消除作用更为明显,能更有效的降低慢性乙型肝炎的致死率,疗效显著,值得在临床上推广及应用。
Objective: To investigate the efficacy of pegylated interferon α-2a combined with bicyclol in the treatment of chronic hepatitis B with high transaminase level. Methods: Sixty-eight patients with chronic hepatitis B were randomly divided into control group and experimental group according to different medication methods. The control group was treated with bicyclol combined with short-acting interferon (Cain probiotics), and the experimental group was treated with peginterferon alfa-2a combined with bicyclol. The serum levels of ALT and AST, serum surface antigens and DNA negative rates of hepatitis B virus were compared between the two groups. Results: After effective treatment, serum ALT and AST levels, serum surface antigen content and DNA negative rate of hepatitis B virus in both groups showed a significant downward trend, but the decline trend of the experimental group was more obvious. Conclusions: Peginterferon alfa-2a combined with bicyclol has more obvious inhibition and elimination effect on hepatitis B virus, and can reduce the lethal rate of chronic hepatitis B more effectively, which is worthy of clinical promotion And application.