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目的对比小剂量~(131)Ⅰ分别联合甲巯咪唑与丙硫氧嘧啶治疗甲状腺功能亢进的临床效果。方法将208例甲状腺功能亢进患者随机分为试验组和对照组各104例。试验组给予小剂量~(131)Ⅰ联合甲巯咪唑治疗,对照组给予小剂量~(131)Ⅰ与丙硫氧嘧啶治疗。对比2组临床疗效和治疗前后血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平和不良反应及复发情况。结果试验组总有效率为94.23%高于对照组的79.81%,差异有统计学意义(P<0.05)。治疗前2组患者血清FT3和FT4水平差异均无统计学意义(P>0.05)。治疗后2组患者上述血清水平均降低,且试验组患者降低程度远大于对照组,差异均具有统计学意义(P<0.05)。试验组不良反应发生率、复发率均低于对照组,差异均有统计学意义(P<0.05)。结论小剂量131I联合甲巯咪唑治疗甲状腺功能亢进的临床综合效果优于丙硫氧嘧啶,且并发症和复发率更低。
Objective To compare the clinical efficacy of low dose 131I with methimazole and propylthiouracil in the treatment of hyperthyroidism. Methods 208 cases of hyperthyroidism were randomly divided into experimental group and control group of 104 cases. The experimental group was treated with low dose 131I combined with methimazole and the control group with low dose 131I and propylthiouracil. The clinical efficacy of two groups were compared before and after treatment with free triiodothyronine (FT3), free thyroxine (FT4) levels and adverse reactions and recurrence. Results The total effective rate of the experimental group was 94.23% higher than 79.81% of the control group, the difference was statistically significant (P <0.05). There was no significant difference in serum FT3 and FT4 levels between the two groups before treatment (P> 0.05). After treatment, the above two groups of patients serum levels were reduced, and the degree of reduction in the test group was much larger than the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions and recurrence in the experimental group were lower than those in the control group, with significant differences (P <0.05). Conclusions The clinical effect of 131I combined with methimazole in the treatment of hyperthyroidism is better than that of propylthiouracil, and the complications and recurrence rate are lower.