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晚近,淋巴细胞和造血的关系日益受到重视,虽然已知胸腺细胞对造血干细胞有一定作用,免疫机制能损害成熟血细胞,但淋巴细胞如何参于造血的调节,以及淋巴细胞功能紊乱对正常造血机制的影响仍所知甚少。近年来,随着实验免疫学和干细胞培养技术的进展,将微量细胞毒技术和干细胞集落分析法适当配合,已有可能在体外研究淋巴细胞各亚群对造血干细胞的调节作用。本文就淋巴细胞和造血的关系作一文献复习。
Recently, the relationship between lymphocytes and hematopoiesis has been paid more and more attention. Although it is known that thymocytes have a certain effect on hematopoietic stem cells and immune mechanisms can damage mature blood cells, how lymphocytes participate in the regulation of hematopoiesis and how lymphocyte dysfunction affects normal hematopoiesis The impact is still poorly understood. In recent years, along with advances in experimental immunology and stem cell culture techniques, it has been possible to investigate the regulatory role of lymphocyte subsets on hematopoietic stem cells in vitro with the appropriate combination of the cytotoxicity assay and the stem cell colony assay. This article reviews the literature on the relationship between lymphocytes and hematopoiesis.