Objective:To explore the expression of HER4 in gastric carcinoma and elucidate the relationship between its overexpression and clinical pathology. Methods:A total of 68 samples of gastric carcinoma were examined for the expression of HER4 by immunohistochemical assay. Results:HER4 was overexpressed in 79.41% of gastric carcinoma.The overexpression of HER4 correlated only with lymph node metastasis and TNM staging. Conclusion:erbB4 is one of the genes to regulate the growth of gastric carcinoma and artificial interference the overexpression of HER4 may be an effective treatment of gastric carcinoma.