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目的:探讨米非司酮配伍米索前列醇用于中期妊娠引产术的疗效。方法:收集我站计生科准备终止中期妊娠的146例患者作为研究对象,分为A组73例和B组73例。A组手术前2天连续服用米非司酮75mg,每天1次,手术日清晨空腹口服米索前列醇0.6mg。B组手术前3天连续服用米非司酮150mg,每日1次。手术日清晨阴道内放置米索前列醇0.6mg。比较两组成功流产率以及阴道流血量及胎儿排出时间。结果:A组16~24周以及初产妇、经产妇的成功流产率与B组差异有统计学意义(P<0.05)。A组与B组阴道流血量、胎儿排出时间差异有统计学意义(P<0.05)。结论:口服150mg米非司酮联合阴道放置米索前列醇对终止中期妊娠疗效肯定。
Objective: To investigate the efficacy of mifepristone with misoprostol in induction of labor during mid-term pregnancy. Methods: A total of 146 patients in our department were enrolled in this study. They were divided into group A (73 cases) and group B (73 cases). A group of two days before surgery, continuous taking mifepristone 75mg, 1 day, fasting morning orally taking misoprostol 0.6mg. B group 3 days before surgery, continuous use of mifepristone 150mg, 1 day. Early morning surgery placed misoprostol 0.6mg vaginal. The successful abortion rate, vaginal bleeding volume and fetal discharge time were compared between the two groups. Results: The difference of successful abortion rate between 16-24 weeks and primipara, mothers in group A and group B was statistically significant (P <0.05). There was significant difference in vaginal bleeding and fetal discharge time between group A and group B (P <0.05). Conclusion: The oral administration of 150mg mifepristone vaginal misoprostol for the termination of midterm pregnancy positive effect.