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回顾性分析1992年1月至1993年12月门诊患者输注抗生素的副反应,不包括HIV感染患者.269例患者共进行291个疗程的抗生素治疗,临床诊断:骨关节感染(59%),血管内感染(16%),脓肿(9%),莱姆病,蜂窝织炎,肺炎,鼻窦炎,泌尿道感染,脑膜炎,眼部感染,神经梅毒等.患者平均年龄49岁,抗生素治疗3～141d(平均40d),每个疗程平均使用2种抗菌药.抗菌药以万古霉素、β-内酰胺类抗生素最常见,其他如氨基糖苷类抗生素、克林霉素、环丙沙星、甲硝唑及两性霉素B等.(1)血液系统不良反应:231个(79%)疗程进行了白细胞计数监测,平均治疗 30d时,36个(16%)疗程出现白细胞减少.万古霉素致白细胞减少发生率13%(14/112),β-内酰胺类抗生素9%(14 /260),头孢唑林10%(9/95).25%(9例)因白细胞减少停药或换药.对186个(64%)疗程进行了中性粒细胞绝对计数监测,13个(7%)疗程发生中性粒细胞减少,出现常较迟,平均在用药后33(±11)d.万古霉素致中性粒细胞减少
A retrospective analysis of side-effects of antibiotics infused in clinics between January 1992 and December 1993 excluding HIV-infected patients was performed.29 A total of 291 courses of antibiotic treatment were performed in 269 patients with clinical diagnosis of osteoarticular infection (59%), (16%), abscess (9%), Lyme disease, cellulitis, pneumonia, sinusitis, urinary tract infections, meningitis, ocular infections, neurosyphilis, etc. The average age of patients was 49 years old and antibiotic treatment 3 ~ 141d (average 40d), with an average of 2 antibacterials per course of treatment.Antimicrobial agents with vancomycin, β-lactam antibiotics are the most common, such as aminoglycoside antibiotics, clindamycin, ciprofloxacin , Metronidazole and amphotericin B, etc .. (1) Adverse reactions to the blood system: WBC count monitoring was performed in 231 (79%) courses and leukopenia occurred in 36 (16%) courses on the average of 30 days. The prevalence of leucopenia was 13% (14/112), β-lactam antibiotics 9% (14/260), cefazolin 10% (9/95) .25% (9 cases) due to leukopenia Or Dressing. Absolute neutrophil counts were monitored in 186 (64%) sessions and neutropenia occurred in 13 (7%) sessions, often later, with an average of 33 (± 11) d. Vancomycin-induced neutropenia