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The c-Jun N-terminal kinases (JNKs) are classic stress-activated protein kinases.Many cellular stresses have beenshown to stimulate JNK activation.In this review,we focus on ribotoxic stresses based on their multiple biologicalpotencies including anti-HIV-1 activity.Some of the functions of ribotoxins and the signaling transduction pathwaythat mediated are mentioned.Different from other stimulators,ribotoxic stresses act on special motifs of 28S rRNAin translationally active mammal ribosomes.Binding and damaging on the motif leads to JNK activation andsubsequently biological response to the signal initiator,which is named ribotoxic stress response.Cellular &Molecular Immunology.2005;2(6):419-425.
The c-Jun N-terminal kinases (JNKs) are classic stress-activated protein kinases. Many cellular stresses have been mutated to stimulate JNK activation. In this review, we focus on ribotoxic stresses based on their multiple biological potential including anti-HIV-1 activity . Home of the functions of ribotoxins and the signaling transduction pathway are mediated are described. Different from other stimulators, signal initiator, which is named ribotoxic stress response. Cellular & Molecular Immunology. 2005; 2 (6): 419-425.