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目的研究分析黏液性宫颈炎(MPC)患者阴道分泌物中细菌感染的常见种类、感染因素、药物敏感试验及治疗方法。方法选取150例确诊为MPC的女性(病例组)、按照1∶1比例选取150例健康女性作为对照组,分别采集两组女性阴道分泌物进行微生物检测,并对病例组进行药物敏感试验分析,根据药物敏感试验结果进行针对治疗。结果两组年龄、卫生习惯、经期性生活史、妇科炎症病史构成比差异无统计学意义(P>0.05);两组人工流产史、性伴侣数量、合并支原体感染率、合并宫颈柱状上皮异位发生率差异均具有统计学意义(P<0.05)。病例组微生物阴性检出率显著低于对照组(P<0.05);病例组细菌及支原体感染率显著高于对照组(P<0.05);两组假丝酵母菌感染率差异无统计学意义(P>0.05)。病例组首次治疗方案采取左氧氟沙星口服+左氧氟沙星胶囊阴道给药、哌拉西林/他唑巴坦+左氧氟沙星胶囊阴道给药两种治疗方案,治愈率达88.00%(132/150),对治疗效果不佳的患者给予丁胺卡那霉素+利奈唑胺+哌拉西林/他唑巴坦给药,最终所有患者均成功治愈。结论 MPC发病与人工流产史、性伴侣数量、合并支原体感染、合并宫颈柱状上皮异位有关,根据药物敏感试验结果选择恰当的治疗方案会提高治愈率。
Objective To study the common types of bacterial infections in vaginal secretions of patients with mucinous cervicitis (MPC), the factors of infection, drug sensitivity test and treatment. Methods 150 female patients diagnosed as MPC (case group) were selected. According to the ratio of 1: 1, 150 healthy women were selected as the control group. Two groups of female vaginal secretions were collected for microbiological examination. The drug susceptibility test of the case group was conducted. According to the drug sensitivity test results for treatment. Results There were no significant differences in age, health habits, menstrual life history and history of gynecological inflammation between the two groups (P> 0.05). The incidence of induced abortion, number of sexual partners, combined infection rate of mycoplasma, The differences were statistically significant (P <0.05). The negative rate of microorganism in case group was significantly lower than that in control group (P <0.05). The infection rate of bacteria and mycoplasma in case group was significantly higher than that of control group (P <0.05). There was no significant difference in the infection rate of Candida between the two groups P> 0.05). The first treatment of the case group to take levofloxacin oral + levofloxacin capsules vaginal administration, piperacillin / tazobactam + levofloxacin capsules vaginal administration of two treatment regimens, the cure rate was 88.00% (132/150), the treatment effect is not good Of patients given amikacin + linezolid + piperacillin / tazobactam administration, and ultimately all patients were successfully cured. Conclusions The incidence of MPC is related to the history of induced abortion, the number of sexual partners, mycoplasma infection combined with cervical columnar epithelial dysplasia. Choosing the appropriate treatment according to the results of drug sensitivity test will improve the cure rate.