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目的探讨淋巴结外Rosai-Dorfman病的病理学特征、诊断及鉴别诊断。方法对2例结外Rosai-Dorfman病行HE和免疫组织化学(EnVisionTM)染色观察。结果光镜下见病灶内深浅不一结节状区域,浅染区体积较大的组织细胞,呈多边形或椭圆形,其直径为淋巴细胞的10～30倍左右,胞质丰富,淡嗜酸性,核膜光滑,有小的嗜碱性核仁,部分组织细胞之胞质内见较多淋巴细胞、浆细胞等,组织细胞表达S100蛋白。结论结外Rosai- Dorfman是一种少见的组织细胞增生性病变,有一定的病理学特征。应与幼年性黄色肉芽肿、纤维组织细胞瘤、Langerhans组织细胞增生症、网状组织细胞瘤以及慢性炎症性病变等鉴别。
Objective To investigate the pathological features, diagnosis and differential diagnosis of Rosai-Dorfman’s disease outside lymph nodes. Methods Two cases of extranodal Rosai-Dorfman’s disease underwent HE and immunohistochemistry (EnVisionTM) staining. Results Light microscope, see the depth of the lesion within the nodular area, light staining area larger volume of tissue cells, polygonal or oval, the diameter of lymphocyte 10 to 30 times, rich in cytoplasm, pale eosinophilic , Nuclear membrane is smooth, a small basophilic nucleolus, some of the cells in the cytoplasm see more lymphocytes, plasma cells, etc., the cells expressed S100 protein. Conclusion Extranodal Rosai-Dorfman is a rare histopathologic lesion with certain pathological features. Should be with juvenile yellow granuloma, fibrous histiocytoma, Langerhans histiocytosis, reticulohistiocytoma and chronic inflammatory lesions and other identification.