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目的为了探讨抗中性粒细胞胞浆抗体(ANCA)对溃疡性结肠炎(UC)的诊断意义。方法采用间接免疫荧光法(IIF)检测52例UC、28例克罗恩病(CD)、36例肠结核和30例健康志愿者的血清ANCA阳性率。结果52例UC患者中,ANCA阳性33例,敏感性63.5%,特异性96.1%,ANCA阳性率与病情轻重、性别、药物治疗等均无关(p>0.05);28例CD患者中,ANCA阳性2例(呈低滴度阳性),敏感性7.1%,特异性56.2%;36例肠结核患者和30例健康志愿者血清中ANCA均呈阴性。结论ANCA对UC的诊断特异性强,可作为UC诊断的一项血清学指标,同时具有重要的鉴别诊断价值。
Objective To investigate the diagnostic significance of anti-neutrophil cytoplasmic antibody (ANCA) on ulcerative colitis (UC). Methods The serum ANCA positive rate of 52 cases of UC, 28 cases of Crohn’s disease (CD), 36 cases of intestinal tuberculosis and 30 healthy volunteers were detected by indirect immunofluorescence assay (IIF). Results Of the 52 patients with UC, ANCA was positive in 33 cases, with a sensitivity of 63.5% and a specificity of 96.1%. The positive rate of ANCA was not related to the severity of illness, sex, medication, etc. (p> 0.05) 2 cases (positive for low titers), the sensitivity was 7.1% and the specificity was 56.2%. The serum ANCA in 36 patients with intestinal tuberculosis and 30 healthy volunteers was negative. Conclusions ANCA is highly specific for the diagnosis of UC and can be used as a serological marker in the diagnosis of UC with important differential diagnostic value.