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无机砷是在地表水或地下水中发现的世界公认的毒物、致癌剂。砷暴露可以引起皮肤病变、生殖系统损害及癌症。人类砷代谢有2种途径:还原反应和甲基化反应,后者是在砷化物上加上甲基基团,形成单甲基砷酸和二甲基砷酸,单甲基砷酸、二甲基砷酸、In-A s从尿中排出。最近研究表明,尿中的另一种类金属物质硒与尿中砷的排出量和砷的甲基化分布有关。为探讨这种关系,在智利进行了砷和生殖效应的前瞻性研究,问卷调查了93个怀孕妇女,内容包括人口学资料、生活习惯以及其他信息。用ICP-M S方法对她们的尿样进行了砷和硒浓度的检测。双变量回归分析发现尿硒与尿砷存在相关性;多元线性回归分析显示,升高的尿硒水平与升高的尿总砷、升高的二甲基砷酸以及下降的In-A s水平有关。研究结果提示,在砷暴露人群中,硒摄入可能和尿中砷的排出有关,并有可能改变砷的甲基化代谢水平。
Inorganic arsenic is a world-recognized poison and carcinogen found in surface water or groundwater. Arsenic exposure can cause skin lesions, reproductive system damage and cancer. Human arsenic metabolism in two ways: the reduction reaction and methylation, which is added to the arsenic methyl groups, the formation of monomethyl arsenic and dimethyl arsenic acid, monomethyl arsenic acid, bis Methyl arsenate, In-A s is excreted from the urine. Recent studies have shown that the urine of another metalloid selenium and urinary arsenic emissions and arsenic methylation distribution. In order to explore this relationship, a prospective prospective study of arsenic and reproductive effects was conducted in Chile. Ninety-three pregnant women were surveyed, including demographic data, lifestyle and other information. Their urine samples were tested for arsenic and selenium concentrations using the ICP-MS method. Bivariate regression analysis showed that there was a correlation between urinary selenium and urinary arsenic. Multivariate linear regression analysis showed that elevated urinary selenium level was associated with elevated urinary total arsenic, elevated dimethyl arsenic acid, and decreased In-A s level related. The results suggest that in people exposed to arsenic, selenium intake may be related to the release of arsenic in the urine, and may change the level of arsenic methylation.