给小鼠腹腔注射（ｉｐ）顺铂（ＣＤＤＰ）０５、１０和１５ｍｇ／ｋｇ，每天１次，连续７天，结果显示，骨髓中多染红细胞（ＰＣＥ）微核率显著增高，呈剂量依赖关系，ＰＣＥ百分数则明显下降。给大鼠ｉｐＣＤＤＰ１０ｍｇ／ｋｇ，或ｉｐＣＤＤＰ前灌胃（ｐｏ）水飞蓟宾（ＳＢ，４０ｍｇ／ｋｇ），每天１次，连续７天。结果显示，停药后第２、５天ＣＤＤＰ组与ＣＤＤＰ＋ＳＢ组ＰＣＥ微核率明显增高，停药后第１０天，增高的ＰＣＥ微核率明显下降；而ＰＣＥ百分比则明显回升。ＳＢ对ＣＤＤＰ所致大鼠微核效应无预防作用，但可预防ＣＤＤＰ引起的ＰＣＥ百分比下降 Mice were intraperitoneally injected with cisplatin (CDDP) 05,10 and 15mg / kg once daily for 7 days. The results showed that the micronuclei of polychromatic erythrocytes (PCE) in the bone marrow were significantly Increased in a dose-dependent manner, the percentage of PCE decreased significantly. Silybin (SB, 40 mg / kg) was given intraperitoneally (ip) to rats ipCDDP 1.0 mg / kg or ipCDDP once daily for 7 days. The results showed that micronuclei of PCDP in CDDP group and CDDP + SB group were significantly increased on the 2nd and 5th days after stopping treatment. On the 10th day after stopping, the increased micronuclei of PCE decreased significantly while the percentage of PCE increased significantly. SB has no prophylactic effect on CDDP-induced micronuclei in rats, but can prevent a decrease in the percentage of PCD caused by CDDP