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目的观察复方天麻提取物对改善小鼠学习记忆功能的作用。方法 120只昆明种雌性小鼠随机分为低、中、高3个剂量组(剂量分别为0.4g/kg BW、0.8g/kg BW、1.2g/kg BW)和阴性对照组。连续灌胃给药30 d后,进行水迷宫试验、跳台试验和避暗试验。一周后,另外取120只小鼠按照相同的试验方法重复上述试验。结果复方天麻提取物可缩短小鼠到达水迷宫终点的时间,可延长小鼠跳台试验的测验潜伏期、减少跳台错误次数,可降低避暗试验的测验错误百分率,差异均有显著性意义。重复试验结果亦为阳性。结论复方天麻提取物具有辅助改善小鼠学习记忆功能的作用。
Objective To observe the effect of compound Gastrodia elata Blume on improving learning and memory in mice. Methods A total of 120 female Kunming mice were randomly divided into three groups: low dose, middle dose and high dose (0.4g / kg BW, 0.8g / kg BW, 1.2g / kg BW) and negative control group. After continuous intragastric administration for 30 days, water maze test, jumping test and dark avoidance test were conducted. One week later, another 120 mice were used to repeat the above test according to the same test method. Results Gastrodia elata extract can shorten the time to reach the end of water maze, prolong the test incubation period of mice, reduce the number of jumps error, reduce the error rate of avoidance test, the difference was significant. Repeated test results are also positive. Conclusion Gastrodia elata Blume extract has the effect of aiding in improving learning and memory in mice.