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[目的]观察芪苈强心胶囊对慢性充血性心力衰竭(CHF)患者血浆B型脑利钠肽(BNP)及D-二聚体浓度的影响。[方法]将106例CHF患者按随机数字表法分为治疗组56例和对照组50例。两组均予以西医利尿、扩血管、强心治疗,治疗组在常规治疗基础上加服芪苈强心胶囊4粒/次,3次/日,疗程4周。两组均于治疗前后采静脉血用免疫荧光定量法快速测定BNP及D-二聚体浓度。[结果]随着心功能的改善,两组病例治疗后血BNP浓度和D-二聚体浓度较治疗前下降,治疗组治疗后BNP及D-二聚体下降均明显高于对照组(P<0.05)。[结论]芪苈强心胶囊能有效降低CHF患者的BNP及D-二聚体浓度。
[Objective] To observe the effect of Qili Qiangxin capsule on plasma B-type natriuretic peptide (BNP) and D-dimer in patients with chronic congestive heart failure (CHF). [Methods] 106 patients with CHF were divided into treatment group (56 cases) and control group (50 cases) by random number table. The two groups were treated with western medicine diuretic, vasodilator and cardiac therapy. The treatment group was given Qiliqiangxin capsule 4 times a day on the basis of routine treatment for 3 times a day for 4 weeks. The levels of BNP and D-dimer in both groups were determined by immunofluorescence quantification before and after treatment. [Results] With the improvement of cardiac function, the blood BNP concentration and D-dimer concentration decreased after treatment in both groups, and the decrease of BNP and D-dimer in the treatment group after treatment was significantly higher than that in the control group (P <0.05). [Conclusion] Qili Qiangxin Capsule can effectively reduce the concentration of BNP and D-dimer in CHF patients.