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目的: 分析青年胃癌的发病特点和病理特征与中老年胃癌的不同特点,为青年胃癌的预防和治疗提供理论依据.方法: 对我院1983 02 /2003 02收治的1839例患者资料进行筛选和研究,对患者性别、发病年龄和病理学类型与分布进行统计分析,并评价遗传因素在胃癌发病中的作用.结果: 青年胃癌以弥漫型多见(40 49% ),病理分型多为低分化腺癌、黏液细胞癌和印戒细胞癌,恶性程度高,女性发病年龄更低,男女性比例接近.具有家族遗传背景或遗传性胃癌患者中青年发病者多于中老年( 39 /189vs69 /1454,P<0 0001; 16 /189vs21 /1454,P<0 0001),男性更易受遗传因素影响.结论: 青年胃癌以高度恶性弥漫型为主,发病呈上升趋势,且与遗传背景有一定的相关性.
Objective: To analyze the characteristics and pathological features of young patients with gastric cancer and the different characteristics of gastric cancer in middle-aged and older adults, and provide theoretical basis for the prevention and treatment of young patients with gastric cancer. Methods: Screening and study of 1839 patients admitted to our hospital from 1983 02 / 2003 02 , Statistical analysis of gender, age of onset, type and distribution of pathology, and evaluation of the role of genetic factors in the pathogenesis of gastric cancer. Results: Youth with diffuse gastric cancer more common (40 49%), pathological type mostly poorly differentiated Adenocarcinoma, mucinous cell carcinoma, and signet-ring cell carcinoma have a high degree of malignancy, and the age of onset of females is lower. The proportion of males and females is close. There are more young and middle-aged patients with family genetic background or hereditary gastric cancer than middle aged (39/189vs69/1454 (P<0 0001; 16/189vs21/1454, P<0 0001). Males are more susceptible to genetic factors. Conclusions: The majority of younger patients with gastric cancer are highly malignant, with an increasing incidence and associated with genetic background. Sex.