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目的针对根尖周炎患牙根管渗出液和龈沟液研究大蒜素对其MMP-8浓度的影响。方法通过对照试验并应用ELISA方法测定测封药前后根管渗出液以及龈沟液中MMP-8浓度的变化。结果从实验结果可以看出,大蒜素和氢氧化钙根管内封药可使根管渗出液和龈沟液中MMP-8浓度显著降低,两者降低根管渗出液中MMP-8的作用比其降低龈沟液中MMP-8的作用要强。在降低MMP-8浓度上大蒜素与氢氧化钙的作用相当。结论大蒜素对根尖周炎根管渗出液和龈沟液中MMP-8水平有影响。
Objective To study the effect of allicin on MMP-8 concentration in root canal exudate and gingival crevicular fluid of periapical periodontitis. Methods The change of MMP-8 concentration in root canal exudate and gingival crevicular fluid before and after the sealant was measured by the control test and ELISA method. Results From the experimental results, we can see that allicin and calcium hydroxide root canal sealant can make root canal exudate and gingival crevicular fluid MMP-8 concentration was significantly reduced, both reduce root canal exudate MMP-8 Is more effective than MMP-8 in gingival crevicular fluid. Allicin has the same effect as calcium hydroxide in reducing MMP-8 concentrations. Conclusion Allicin has an effect on the level of MMP-8 in root canal exudate and gingival crevicular fluid.