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目的探讨系统性红斑狼疮 (SL E)患者血清泌乳素与性激素水平的关系。方法采用放射免疫分析法检测 3 5例 SLE患者泌乳素、雌二醇、睾酮及黄体生成素的水平。结果 SL E患者平均泌乳素水平比对照组明显升高 (P<0 .0 1) ,以活动期更为显著 ;同时 ,活动期患者的雌二醇水平比对照组升高 (P<0 .0 1)。 3 5例患者的睾酮水平均有明显下降 ,与对照组比有非常显著差异 (P<0 .0 1) ;雌二醇 /睾酮比显著升高 ,泌乳素水平与雌二醇水平呈正相关。结论泌乳素与 SL E的发病率及病情活动密切相关 ;这可能与雌激素的分泌异常有关 ;而雄激素则能维护免疫系统的正常功能
Objective To investigate the relationship between serum prolactin and sex hormones in patients with systemic lupus erythematosus (SL E). Methods The levels of prolactin, estradiol, testosterone and luteinizing hormone in 35 SLE patients were detected by radioimmunoassay. Results The average prolactin level in patients with SL E was significantly higher than that in the control group (P <0.01), and the activity was more significant. Meanwhile, the activity of estradiol in SL E patients was higher than that of the control group (P <0. 0 1). Serum testosterone levels were significantly decreased in all 35 patients, compared with the control group (P <0.01); the estradiol / testosterone ratio was significantly increased; and the prolactin level was positively correlated with estradiol levels. Conclusions Prolactin is closely related to the incidence and activity of SL E, which may be related to the abnormal secretion of estrogen. Androgen can maintain the normal function of the immune system