可改变的心血管病危险因素包括几种能受高血压药物治疗影响者,这些危险因素,现已超过由Framigham的研究及其他长期、大规模的流行病学调查所总结的传统的因素。这些增加的因素包括身体上部的肥胖,以及高血压,葡萄糖耐受不良,高脂血症,所有这些均由高胰岛素血症所介导。高血压的治疗,已在病人数量和药物两者均有增加,现在应当关注治疗对心血管病患病率,死亡率及对个体危险因素的影响。如同Collins等人所概述的那样,14次抗高血压药物为试验,已经检验了药 Alterable cardiovascular risk factors include several that can be affected by the treatment of hypertension drugs and these risk factors have now surpassed the traditional ones summarized by Framigham’s research and other long-standing, large-scale epidemiological investigations. These added factors include upper body obesity, as well as high blood pressure, impaired glucose tolerance, hyperlipidemia, all mediated by hyperinsulinemia. The treatment of hypertension has increased both in numbers of patients and drugs and attention should now be given to the impact of treatment on cardiovascular morbidity, mortality and risk factors for individuals. As outlined by Collins et al., 14 antihypertensives were tested and drugs have been tested