胰岛素受体与胰岛素结合后发生自身磷酸化并磷酸化底物,启动受体后信号传导途径,在胰岛素促代谢、促细胞生长繁殖作用中起重要作用。血管内皮生长因子(VEGF)参与肿瘤发生与发展、缺血性血管病变、糖尿病小血管异常增生等多种病理生理过程,受缺氧、多种生长因子、高胰岛素水平等多种因素的调控。胰岛素受体及其底物作为VEGF的调控因素之一可通过多种途径影响VEGF的表达。 Insulin receptor binding to insulin autophosphorylation and phosphorylation of substrates, start signaling pathway after the receptor, in insulin metabolism, promote cell growth and reproduction play an important role. Vascular endothelial growth factor (VEGF) is involved in a variety of pathophysiological processes such as tumorigenesis and development, ischemic vascular disease, and diabetic small vessel dysplasia, and is regulated by many factors such as hypoxia, multiple growth factors and high insulin levels. Insulin receptor and its substrate as a regulator of VEGF can affect VEGF expression in a variety of ways.