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目的:分析系统性红斑狼疮合并甲状腺功能减退症50例临床症状和治疗效果。方法:选取2010年6月至2012年6月间于我院接受诊断和治疗的系统性红斑狼疮合并甲状腺功能减退症患者50例作为观察组,同时选取同期入院的单纯系统性红斑狼疮患者50例作为对照组,分析两组临床症状的差异。观察组患者分别给予系统性红斑狼疮合并甲状腺功能减退症联合治疗和甲状腺功能减退症单独治疗,观察比较治疗前后甲状腺功能差异。结果:观察组患者关节病变发病率为64.00%明显高于对照组的22.00%(P<0.05);观察组患者雷诺现象的发病率为36.00%明显高于对照组的6%(P<0.05)。联合治疗患者治疗后促甲状腺素水平明显低于单独治疗(P<0.05),联合治疗患者治疗后游离甲状腺素和游离甲状腺三碘原氨酸水平均明显高于单独治疗(P<0.05)。结论:系统性红斑狼疮合并甲状腺功能减退症患者的关节病变和雷诺现象发病率明显较高,联合治疗后甲状腺功能减退症恢复较佳。
Objective: To analyze the clinical symptoms and treatment effect of 50 cases of systemic lupus erythematosus complicated with hypothyroidism. Methods: Fifty patients with systemic lupus erythematosus complicated with hypothyroidism undergoing diagnosis and treatment in our hospital from June 2010 to June 2012 were selected as the observation group. Fifty patients with systemic lupus erythematosus As a control group, the differences of clinical symptoms between the two groups were analyzed. Patients in the observation group were given systemic lupus erythematosus combined with hypothyroidism and hypothyroidism alone, before and after treatment to observe the difference in thyroid function. Results: The incidence of joint disease was 64.00% in observation group and 22.00% in control group (P <0.05). The incidence of Raynaud’s phenomenon in observation group was significantly higher than that in control group (36.00% vs 6%, P <0.05) . After treatment, the level of thyroxine was significantly lower in combination therapy group than in treatment group (P <0.05). The levels of free thyroxine and free thyroxine in patients with combination therapy were significantly higher than those in treatment group alone (P <0.05). Conclusions: The incidence of joint disease and Raynaud’s phenomenon in patients with systemic lupus erythematosus complicated with hypothyroidism is significantly higher. Hypothyroidism recovery after combination therapy is better.