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德国研究人员宣布,他们成功合成了一种针对8型肺炎链球菌的多糖疫苗,这种疫苗不仅制作简单,成本也较传统疫苗低。细菌表面的多糖具有强免疫原性,能够刺激机体形成抗体,科学家经常使用细菌表面特有的多糖来制作疫苗,但分离出多糖并不容易,且成本较高。为此,研究人员选择人工合成这些多糖,再将其与载体蛋白结合制成疫苗。8型肺炎链球菌是一种可引发严重肺炎和脑膜炎的高毒性细菌,并且常常对现有抗生素显现出耐药性。研究人员采用一种自动合成的方法,先将
German researchers announced that they have successfully synthesized a polysaccharide vaccine against Streptococcus pneumoniae type 8, which is not only simple to make but also less costly than traditional vaccines. Bacterial polysaccharides on the surface of the strong immunogenicity, can stimulate the body to form antibodies, scientists often use bacteria-specific surface polysaccharides to make vaccines, but the separation of polysaccharides is not easy and costly. To this end, the researchers chose to artificial synthesis of these polysaccharides, and then combined with the carrier protein vaccine. Streptococcus pneumoniae type 8 is a highly toxic bacterium that can cause severe pneumonia and meningitis and often shows resistance to existing antibiotics. The researchers used an automatic synthesis method, first