1病例报告患者男,23岁。因失眠、兴趣下降、情绪低落、易激惹、凭空闻声6个月住院。检查:意识清楚,接触被动,问答切题,注意力尚集中,检查较合作。未查及明显的感知综合障碍,存在言语幻听及被害观念情绪低落,情感反应、内心体验与周围环境尚协调,智能及定向力正常,自知力部分存在。入院诊断为重度抑郁发作,伴精神病性症状(F 32.3)。给予草酸艾司西酞普兰 1 case report patient male, 23 years old. Due to insomnia, decreased interest, depression, irritability, out of hearing heard in hospital for 6 months. Check: Consciousness, contact passive, questions and answers, attention is still focused, check more cooperation. Undetected and obvious perceived comprehensive barriers, there is a sense of language and auditory hallucinations mood depression, emotional reaction, inner experience and the environment is still coordinated, intelligence and orientation of the normal part of the self-knowledge exists. Admission was diagnosed as a major depressive episode with psychotic symptoms (F 32.3). Escitalopram oxalate was given