Objective:To study the clinical efifcacy of midazolam in the treatment of 224 patients with status epilepticus (SE). Methods:A total of 224 patients with status epilepticus (SE) admitted in our hospital from October, 2010 to October, 2013 were selected and randomly divided into midazolam group (n = 144) and combination group (tranquillizer + phenobarbital) (n = 80). 0.1 ~ 0.2 mg/kg of midazolam were slowly given to midazolam group for 5 ~ 10 min while 0.3 ~ 0.5 mg/kg of diazepam and 5 ~ 10 mg/kg of phenobarbital were intramuscularly injected to patients in combination group. Results:SE’s time was signiifcantly controlled in midazolam group than in combination group, while it was suggested that SE children’s age, etiology, incentives, seizure type, EEG, imaging changes were independent with the short-term efficacy of SE patients (P > 0.05), and the duration of attack, treatment programs and short-term efifcacy of SE were correlated (P