2例女性癫痫患者(例1 15岁,例2 54岁),服用传统抗癫痫药物效果不佳,给予口服左乙拉西坦0.25 g2,次/d,分别在治疗第75、天,四肢及躯干部皮肤出现红色斑疹伴瘙痒。考虑皮疹与左乙拉西坦有关。例1停用左乙拉西坦后3 d皮疹消褪。例2停用左乙拉西坦并接受氯雷他定10 mg、1次/d治疗,1周后皮疹消褪。 Two cases of epilepsy in women (aged 15 years and 545 years old) were treated with traditional antiepileptic drugs ineffectively. Patients were given oral levetiracetam 0.25 g twice a day for 75 days, limbs and Trunk skin red patches appear with itching. Consider rash and levetiracetam related. Example 1 The skin rash disappeared 3 days after the withdrawal of levetiracetam. Example 2 Levodisitan was discontinued and received loratadine 10 mg once daily, after which the rash subsided.