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目的探讨腹腔镜与开腹手术治疗卵巢良性肿瘤对患者免疫功能的影响。方法2009年1月至2013年1月收治的138例卵巢良性肿瘤患者,按照治疗方法分为腹腔镜组(68例)和开腹组(70例)。比较两组患者术中出血量、术后镇痛率、术后恢复排气时间、术后并发症发生率以及免疫功能。结果腹腔镜组患者的术中出血量、术后镇痛率、术后恢复排气时间及术后并发症发生率均明显低于开腹组,差异有统计学意义(P<0.05)。腹腔镜组患者术后24h CD+3T细胞比率、CD+4T细胞比率、CD+3T/CD+4T细胞比值明显高于开腹组,差异有统计学意义(P<0.05)。腹腔镜组术后24h IgG的水平明显高于开腹组患者,差异有统计学意义(P<0.05)。结论腹腔镜手术以其创伤小、术中出血量少、术后镇痛率低等优点成为治疗卵巢良性肿瘤的重要术式,同时可以较好地保护患者机体的细胞免疫和体液免疫功能,值得临床推广应用。
Objective To investigate the effect of laparoscopy and laparotomy on benign ovarian tumors on immune function. Methods One hundred and thirty-eight patients with benign ovarian tumors who were admitted from January 2009 to January 2013 were divided into laparoscopic group (68 cases) and open group (70 cases) according to the method of treatment. The blood loss, postoperative analgesia, postoperative recovery exhaust time, incidence of postoperative complications and immune function were compared between the two groups. Results The intraoperative blood loss, postoperative analgesia rate, postoperative recovery exhaust time and postoperative complication rate in laparoscopic group were significantly lower than those in open group (P <0.05). The ratio of CD + 3T cells, CD + 4T cells and CD + 3T / CD + 4T cells in laparoscopic group were significantly higher than those in laparotomy group after 24h, the difference was statistically significant (P <0.05). The level of IgG in the laparoscopic group was significantly higher than that in the open group (P <0.05). Conclusions Laparoscopic surgery is an important technique for the treatment of benign ovarian tumors because of its small trauma, less intraoperative blood loss and less postoperative analgesia. It is also worthwhile to protect the cellular and humoral immune functions of patients. Clinical application.