目的:探讨七氟醚全程吸入麻醉在二尖瓣置换术中应用价值。方法:选取于本院行二尖瓣置换术患者94例，随机数字表法分为对照组(n n＝47)与观察组(n n＝47)。对照组全程靶控输注丙泊酚，观察组全程吸入七氟醚。统计两组术后情况(ICU停留时间、气管导管拔除时间、心脏自主复跳情况)、不同时间段血流动力学指标[平均动脉压(MAP)、心率(HR)]、血清肌酸磷酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)及丙二醛(MDA)、超氧化物歧化酶(SOD)水平，随访1个月，统计两组主要不良心血管事件(MACE)发生率。n 结果:⑴术后情况：观察组ICU停留时间、气管导管拔除时间短于对照组，心脏自主复跳率(93.62%)高于对照组(72.34%)(n P0.05)；⑶CK-MB及cTnI：主动脉开放2、6、24、48 h后两组血清CK-MB及cTnI水平高于麻醉诱导前，但观察组各指标水平低于对照组(n P<0.05)；⑷MDA及SOD：主动脉开放2、6、24、48 h后两组血清SOD水平较麻醉诱导前降低、MDA水平较麻醉诱导前增高，且观察组SOD水平高于对照组、MDA水平低于对照组(n P<0.05)；⑸MACE：观察组MACE发生率(12.77%)低于对照组(29.79%)(n P<0.05)。n 结论:二尖瓣置换术中应用七氟醚全程吸入麻醉可维持血流动力学稳定，术后ICU停留及气管导管拔除时间短，血清CK-MB、cTnI、MDA及SOD水平波动幅度小，且利于降低MACE的发生风险。“,”Objective:To explore the application value of sevoflurane inhalation anesthesia in mitral valve replacement.Methods:A total of 94 patients who underwent mitral valve replacement in our hospital (October 2016-October 2018) were randomly divided into the control group (n n=47) and the observation group (n n=47). The control group received target-controlled infusion of propofol, and the observation group inhaled sevoflurane.The postoperative conditions [intensive care unit (ICU) stay time, extubation time of tracheal tube, spontaneous cardiac rebound], hemodynamic indexes [mean arterial pressure (MAP), heart rate (HR)], serum creatine phosphokinase isoenzyme (CK-MB), cardiac troponin I (cTnI), malondialdehyde (MDA) and superoxide dismutase (SOD) in the two groups were analyzed. The patients were followed up for one month. The incidence of major adverse cardiovascular events (MACE) was calculated.n Results:⑴ Postoperative situation: the time of stay in ICU and extubation of tracheal tube in the observation group was shorter than that in the control group, and the rate of spontaneous cardiac rebound (93.62%) was higher than that in the control group (72.34%) (n P0.05); ⑶ CK-MB and cTnI: the levels of serum CK-MB and cTnI in the two groups were higher at 2, 6, 24, and 48 h after aortic cross-clamp release than before anesthesia induction, but the indicators of the observation group were lower than those in the control group; ⑷ MDA and SOD: the serum SOD level in the two groups at 2, 6, 24, and 48 h after aortic cross-clamp release were lower than before anesthesia induction, and the MDA level in the two groups at 2, 6, 24, and 48 h after aortic cross-clamp release were higher than before anesthesia induction. The level of SOD in the observation group was higher than that in the control group, and the level of MDA was lower than that in the control group (n P<0.05); ⑸ MACE: the incidence of MACE in the observation group (12.77%) was lower than that of the control group (29.79%) (n P<0.05).n Conclusions:During mitral valve replacement, sevoflurane inhalation anesthesia can maintain hemodynamic stability. The duration of ICU stay and tracheal tube extubation time is shorter, and the fluctuation of serum CK-MB, cTnI, MDA and SOD is small, and it can reduce the risk of MACE.