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目的比较子痫前期患者中合并胎儿生长受限与不合并生长受限孕妇体内血清游离脂肪酸(FFA)水平。方法本研究随机抽取2014年9月-2015年5月在郑州大学第三附属医院分娩的子痫前期患者50例,其新生儿出生体重正常的28例,低出生体重22例。分为子痫前期组(PE组)和子痫前期合并生长受限组(PE+IUGR组)。以同期正常分娩患者30例为对照组。用改良铜试剂比色法检测孕妇血清FFA水平。结果 1 PE组及PE+IUGR组新生儿出生体重分别为(2464±729.391)g及(1684±481.908)g,对照组新生儿出生体重为(2850±446.442)g,3组间进行多组均数两两比较的LSD-t检验,差异均有统计学意义(P<0.05)。2PE组和PE+IUGR组孕妇血清游离脂肪酸水平分别为(569.45±24.03)mmol/L及(696.77±71.73)mmol/L,均高于对照组(452.84±63.87)mmol/L,分别比较,差异均有统计学意义(P<0.05);PE+IUGR组血清游离脂肪酸水平高于PE组,差异有统计学意义(P<0.05)。结论血清FFA水平升高可能是子痫前期发病的重要因素,血清FFA水平过高可能导致子痫前期合并胎儿生长受限,影响预后。
Objective To compare the level of serum free fatty acid (FFA) in preeclampsia patients with and without fetal growth restriction. Methods Fifty patients with preeclampsia who were delivered at the Third Affiliated Hospital of Zhengzhou University from September 2014 to May 2015 were randomly selected. The newborns had 28 normal birth weight and 22 low birth weight. Divided into preeclampsia group (PE group) and preeclampsia combined with growth restriction group (PE + IUGR group). In the same period normal delivery patients 30 cases as control group. Determination of serum FFA levels in pregnant women by modified copper reagent colorimetry. Results The birth weights of neonates in PE and PE + IUGR groups were (2464 ± 729.391) g and (1684 ± 481.908) g, respectively. The birth weight of newborns in control group was (2850 ± 446.442) g. The number of LSD-t test was significantly different between the two groups (P <0.05). The levels of serum free fatty acid in pregnant women with 2PE and PE + IUGR were (569.45 ± 24.03) mmol / L and (696.77 ± 71.73) mmol / L, respectively, higher than those in the control group (452.84 ± 63.87) mmol / L, (P <0.05). The level of serum free fatty acid in PE + IUGR group was higher than that in PE group, with statistical significance (P <0.05). Conclusions Elevated serum FFA levels may be an important factor in the pathogenesis of preeclampsia. Excessive levels of serum FFA may result in the restriction of fetal growth in preeclampsia and prognosis.