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红霉素是仍在临床上使用的并作为检验此类相关化合物作用和副作用标准的最古老的大环内酯.早在1983年,即有人报道其对胃肠运动的直接作用.红霉素在治疗剂量范围内可中断进食前后的运动模式,立即增加胃和小肠上段蠕动持续至少3小时.口服250～500mg可激发呕吐并中断胃肠蠕动模式.据报告十四元大环内酯类红霉素roxithromycin,clarithromycin,oleandomycin增加胃肠蠕动,而十六元化合物,麦迪霉素,白霉素,交沙霉素和乙酰螺旋霉素则无蠕动作用.用管内压力导体研究显示:10/14的健康志愿者接受口服或静脉给予治疗剂量红霉素后出现从腹鸣到呕吐的副作用.静脉给红霉素7mg/kg立即增加胃的收缩幅度和频率.这种活度增加仅限于胃和上十二指肠,而远端小肠蠕动抑制.静脉内给500mg引起因胃窦收缩所致上腹痛,腹胀和恶心.
Erythromycin is still in clinical use and serves as the oldest macrolide to test the effects and side effects of such related compounds, and its direct effect on gastrointestinal motility has been reported since 1983. Erythromycin In the therapeutic dose range can be interrupted before and after eating mode of exercise, immediately increase the stomach and upper intestinal peristalsis lasts at least 3 hours.Oral 250 ~ 500mg can stimulate vomiting and disruption of gastrointestinal motility.According to the report fourteen yuan macrolide red Ciclosporin roxithromycin, clarithromycin, oleandomycin increase gastrointestinal motility, and 16 yuan compound, midecamycin, white mold, jasamycin and acetylspiramycin have no peristalsis. With the tube pressure conductor study showed: 10/14 Of healthy volunteers received oral or intravenous administration of erythromycin at doses ranging from vomiting to vomiting.Veginomycin 7 mg / kg intravenously immediately increased the amplitude and frequency of gastric contraction.This increase in activity was limited to the stomach and On the duodenum, and distal intestinal peristalsis inhibition.Intravenous to 500mg caused by abdominal antral contraction caused by abdominal pain, abdominal distension and nausea.