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目的探究慢性乙肝病毒(hepatitis B virus,HBV)携带丙氨酸氨基转移酶(alanine aminotransferase,ALT)、谷草转氨酶(aspertate aminotransferase,AST)及乙型肝炎E抗原(hepatitis B e antigen,HBeAg)与血清HBV DNA含量的关系。方法选取2013年9月-2017年3月我院收治的口腔疾病患者中63例慢性HBV携带患者与37例轻度乙型肝炎患者,检测其ALT、AST、HBeAg水平及血清HBV DNA载量,分析慢性HBV携带患者ALT、AST、HBeAg水平及血清HBV DNA载量之间的关系;将63例慢性HBV携带者按照HBV DNA载量分为3组,分析ALT、AST及HBeAg与HBV DNA不同载量的关系。结果慢性HBV携带患者ALT、AST与轻度乙型肝炎患者相比差异具有统计学意义(P<0.05),HBeAg~+发生率相比差异无统计学意义(P>0.05);ALT及AST水平随HBV DNA载量上升而升高,中拷贝与高拷贝ALT相比差异显著(P<0.05),AST相比差异无统计学意义(P>0.05);HBeAg~+患者数量随HBV DNA载量升高而变多,HBeAg-患者数量随HBV DNA上升整体呈下降趋势,HBeAg~+组中血清HBV DNA载量与HBeAg-组相比明显较多(P<0.05);ALT及HBeAg~+与HBV DNA载量呈正相关,AST与HBV DNA载量无明显相关性。结论慢性HBV携带患者的肝功能损害不明显,但病毒复制活跃,ALT可反映肝细胞损害程度,特异性较高,ALT及HBeAg与血清HBV DNA载量相关性良好,AST与血清HBV DNA无明显相关性。
Objective To investigate the relationship between hepatitis B virus (HBV) and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and hepatitis B e antigen (HBeAg) HBV DNA content of the relationship. Methods From September 2013 to March 2017, 63 patients with chronic HBV carriers and 37 mild hepatitis B patients with oral diseases admitted to our hospital were enrolled in this study. ALT, AST and HBeAg levels, serum HBV DNA load, The relationship between ALT, AST, HBeAg levels and serum HBV DNA load in patients with chronic HBV carriers was analyzed. Sixty-three chronic HBV carriers were divided into three groups according to the HBV DNA load. The levels of ALT, AST, HBeAg and HBV DNA The amount of relationship. Results There was no significant difference in the incidence of HBeAg ~ + between patients with chronic HBV carriers and those with mild hepatitis B (P <0.05). The levels of ALT and AST (P <0.05). There was no significant difference between AST and AST (P> 0.05). The number of patients with HBeAg ~ + increased with the increase of HBV DNA load, (P <0.05). The serum HBV DNA load in HBeAg ~ + group was significantly higher than that in HBeAg- group (P <0.05). The levels of ALT and HBeAg ~ + HBV DNA load was positively correlated, AST and HBV DNA load no significant correlation. CONCLUSIONS: Patients with chronic HBV infection have no significant hepatic impairment, but viral replication is active. ALT can reflect the degree of hepatocellular damage and specificity. There is a good correlation between ALT and HBeAg and serum HBV DNA load, but no significant difference between AST and serum HBV DNA Correlation.