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目的：比较研究前列腺特异抗原（PSA）和游离PSA与前列腺癌和增生腺体体积的关系及其在前列腺癌诊断中的价值．方法：41例前列腺增生（BPH）和22例前列腺癌患者，术前用放免法测定血清PSA和游离PSA．所有患者经直肠腔内B超测出前列腺体积，用t检验和相关分析比较研究．结果：前列腺癌组PSA、FPSA均显著高于BPH组．两组的F/TPSA比值无显著差异（P＞0．05）。BPH组PSA与前列腺体积具相关性，前列腺癌无此特点，FPSA和F／TPSA均与腺体体积无关．结论：PSA在BPH者与前列腺体积有关，故PSAD有助于区分前列腺癌和BPH，但游离PSA无此相关性，且无法帮助鉴别诊断．
Objective: To compare the relationship between prostate-specific antigen (PSA) and free PSA with the volume of prostate and hyperplastic glands and their value in the diagnosis of prostate cancer. Methods: Thirty-one patients with benign prostatic hyperplasia (BPH) and 22 patients with prostate cancer were enrolled. Serum PSA and free PSA were measured by radioimmunoassay before operation. All patients underwent transrectal B-ultrasound prostate volume measured by t-test and correlation analysis of comparative study. Results: PSA and FPSA in prostate cancer group were significantly higher than those in BPH group. There was no significant difference in F / TPSA ratio between the two groups (P> 0.05). There was a correlation between PSA and prostate volume in BPH group. There was no such characteristic in prostate cancer. FPSA and F / TPSA had no relation with glandular volume. Conclusion: The PSA in BPH is related to the volume of prostate. Therefore, PSAD can help differentiate prostate cancer from BPH. However, no correlation exists between free PSA and can not help in differential diagnosis.