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为探讨白细胞介素１对肾小球系膜细胞作用的细胞内信号转导机制，采用３Ｈ胸腺嘧啶参入、免疫沉淀及激酶磷酸化反应等方法，检测了白细胞介素１对分裂原活化蛋白激酶不同亚类的作用，并与血小板衍生生长因子的作用进行比较。结果发现，与血小板衍生生长因子的作用相反，白细胞介素１可在短时间内激活ｃｊｕｎ氨基末端激酶，但对ｐ４２／４４分裂原活化蛋白激酶无刺激作用，表明白细胞介素１在肾小球系膜细胞的作用可通过ｃｊｕｎ氨基末端激酶介导，可能是其生物学效应与血小板衍生生长因子不同的细胞内机制之一
To investigate the role of IL-1 in the mesangial cell signaling pathway, 3H-thymidine incorporation, immunoprecipitation and kinase phosphorylation were used to detect the effect of interleukin-1 on mitogen-activated protein The role of different subtypes of kinases is compared with that of platelet-derived growth factor. The results showed that, contrary to the role of platelet-derived growth factor, interleukin 1 activates c-jun amino-terminal kinase in a short time, but no stimulation of p42 / 44 mitogen-activated protein kinase, indicating that interleukin-1 in the kidney The role of mesangial cells can be mediated by c-jun amino-terminal kinase may be its biological effects and platelet-derived growth factor different from one of the intracellular mechanisms