【摘 要】
：
IntroductionMetformin (1,1-dimethylbiguanide) (Fig. 1) is an oral anti-hyperglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus (typ
【机 构】
：
Research Center for Drug Metabolism
论文部分内容阅读
IntroductionMetformin (1,1-dimethylbiguanide) (Fig. 1) is an oral anti-hyperglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus (type Ⅱ). Owing to its weight-decreasing and serum lipid-normalizing effects, it is especially recommended for obese patients[1,2] Various analytical methods have been described for the measurement of metformin in biological fluids, including gas chromatography(GC)[3-5], capillary electrophoresis (CE)[6] and HPLC[7～16]with UV detection[7-12,17] HPLC-Mass spectrometry (LC/APCIMS/MS ) offers an attractive alternative to HPLC[18].
其他文献
IntroductionRecent years, chalcopyrite semiconductors have been successfully applied as absorber layers for polycrystalline thin-film solar cells. Among the ter
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
The title compound, spiro[1-bromo(S)-4-(R)-hydroxy-5-oxa-6-oxo-bicyclo[3.1.0]-hxane-2,2'-(3'-diethyl-α-(S)-4''-Cl-benzyloxyphosphonyl-4'-(1R,2S,5R)-menthyloxyb
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
A complex optical model potential correlated by the concept of bonded atom, which considers the overlapping effect of electron clouds between two atoms in a mol
The existence of solutions for second order three-point boundary value problems with nonlinear growth at resonance is studied by using Mawhin continuation theor
The title compound (C25H24N4O3) has been prepared by the cyclocondensation of 5-amino-3-methyl-1-phenypyrazol, m-nitrobenaldehyde and dimedone in glycol under m
Utilizing the improved model with quasi-coherent two-quantum state and new Hamiltonian containing an additional interaction term [Phys. Rev. E62 (2000) 6989 and
ZSM-5/β co-crystalline zeolites with different content of ZSM-5 have been synthesized by adding different amount of ZSM-5 to the synthetic system ofβ zeolite
A new inclusion complex thiourea with tetrabutylammonium salicylate and water,4(C4H9)4N+C7H5O3-.4(NH2)2CS.2H2O, has been prepared and characterized by X-ray cry