目的　研究肝癌介入治疗后 ,周围正常肝脏细胞是否存在肝细胞凋亡及再生及其特点。方法　VX2肝癌动物模型兔 50只 ,分别行肝叶切除术 (PH)与经动脉化疗栓塞术 (TACE) ,流式细胞术检测术后 2 4、72h的周围正常肝细胞周期 ,测定S期细胞比率 (SPF) ,增殖指数 (PI)的变化并测定是否有肝细胞凋亡。结果　TACE术后 2 4hSPF、PI较对照组均明显升高 (P <0 .0 0 1 ) ,并且术后第 1天 ,TACE术后肝细胞增殖弱于肝叶切除术 ,各项指标差异有显著性 (P <0 .0 5) ,术后 72h ,两组出现较小的亚二倍体峰 (Sub G1 ) ,较对照组有所升高 (P <0 .0 5) ,但它们之间差异无显著性 (P >0 .0 5)。结论　TACE术后肝组织存在一定程度的再生和肝细胞凋亡 ,这可能与碘油的选择性栓塞 ,化疗药物的诱导和自由基的损伤有关 Objective To investigate the hepatocyte apoptosis, regeneration and its characteristics in normal liver cells after interventional treatment of liver cancer. Methods Fifty VX2 hepatocarcinoma model rabbits were subjected to hepatectomy (PH) and transcatheter arterial chemoembolization (TACE). Flow cytometry was used to detect the normal liver cell cycle at 24 and 72 hours after operation. (SPF), proliferation index (PI) changes and determine whether there is hepatocyte apoptosis. Results At 24 hours after TACE, the levels of SPF and PI were significantly higher than those in the control group (P <0.01). On the first postoperative day, the hepatocyte proliferation was weaker than that of the hepatectomy after TACE. The differences of the indexes (P <0.05), and the sub-diploid peak (Sub G1) appeared in both groups at 72h after operation, which was significantly higher than that of the control group (P <0.05) There was no significant difference between the two groups (P> 0.05). Conclusions There is a certain degree of regeneration and hepatocellular apoptosis in liver tissue after TACE, which may be related to the selective embolization of lipiodol, the induction of chemotherapeutic drugs and the injury of free radicals