目的目的探讨９０年代致病真菌的分布及动态变化．方法将患者标本接种于含氯霉素的葡萄糖蛋白胨琼脂培养基（ｃＳＡＢ）或含氯霉素及放线菌酮的葡萄糖蛋白胨琼脂培养基（ａｃＳＡＢ）上，置２５℃一２７℃温箱孵育．根据菌落特征、镜下结果鉴定其菌种，分类统计后与８０年代结果比较分析．结果分离的３８１株致病真菌中，红色毛癣菌居首位，须癣毛癣菌次之，再次为孢子丝菌；深部真菌病明显上升，浅部真菌病，尤其是头癣菌菌相有了较大变化．结论真菌病发病率上升．一些抗真菌药的广泛应用及其对敏感致病真菌的抑制作用，导致耐药菌株相对增多，使致病真菌菌相发生变化． Objective To investigate the distribution and dynamics of pathogenic fungi in the 1990s. Methods Patient specimens were inoculated on chloramphenicol dextrin peptone agar medium (cSAB) or chloramphenicol and cycloheximide agarose agar medium (acSAB), incubated at 27 ° C in an incubator at 25 ° C. According to the characteristics of colonies, the strains were identified by microscopic examination, and the results were compared with those of the 1980s after classification and classification. Results Among the 381 pathogenic fungi isolated, Trichophyton rubrum was the highest, followed by Trichophyton mentagrophytes, and again to Sporotrichosis; the mycosis was significantly increased, and the superficial mycosis, especially Trichophyton mentagrophytes There have been major changes. Conclusion The incidence of fungal disease increased. The widespread use of some antifungal agents and their inhibition of sensitive pathogenic fungi, resulting in a relative increase in drug-resistant strains, the pathogenic fungal bacteria change.