论文部分内容阅读
[目的]观察慢性乙型肝炎的优化抗病毒治疗方法及效果。[方法]选择慢性乙型肝炎初治患者84例,随机分为A组、B组、C组;A组28例单用阿德福韦酯(ADV)10mg口服治疗,B组25例单用普通干扰素(IFN)500万U肌肉注射治疗,C组31例给予ADV联合普通IFN治疗;3组疗程均为48周。[结果]C组ALT复常率83.9%、HBeAg阴转率64.5%、HBeAg/抗-HBe转换率35.5%、HBV-DNA阴转率77.4%,较A组、B组均明显提高(P<0.01)。[结论]ADV联合IFN优化治疗慢性乙型肝炎,可明显提高疗效。
[Objective] To observe the optimized anti-virus therapy and its effect in chronic hepatitis B. [Method] Eighty-four patients with newly diagnosed chronic hepatitis B were randomly divided into group A, group B and group C. A group of 28 patients were treated with adefovir dipivoxil (ADV) 10 mg orally, and group B 25 patients Normal Interferon (IFN) 5 million U intramuscular injection treatment, C group 31 cases were given ADV combined with ordinary IFN treatment; 3 courses of treatment were 48 weeks. [Results] The recovery rate of ALT in group C was 83.9%, the rate of HBeAg negative conversion was 64.5%, the rate of HBeAg / anti-HBe conversion was 35.5% and the rate of HBV DNA negative conversion was 77.4% in group C, which was significantly higher than those in group A and B (P < 0.01). [Conclusion] ADV combined with IFN optimal treatment of chronic hepatitis B, can significantly improve the efficacy.